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Infinite Regress

blog.miljko.org · English

Clinical trials, cancer research, book reviews, coffee making, photography, and the like.

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Sep 16, 2026
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  1. https://blog.miljko.org/2026/09/15/dictated-the-first-draft-of.html
    Sep 16, 2026 · original
    Dictated the first draft of this from an Index 01 . Integration with Micro.blog isn t there yet but at some point I might be writing blog posts with only my left index finger.
  2. https://blog.miljko.org/2026/09/11/without-having-seen-this-weeks.html
    Sep 11, 2026 · original
    Without having seen this week s Apple event, I can feel it in my bones that the future of pocket devices is something small that can on demand turn into something big. No, I m not preordering — for reasons — but surely the matte screen and other crease-hiding trickery will at some point trickle down to a sub-$1,000 inflation-adjusted level. I can wait.
  3. https://blog.miljko.org/2026/09/07/clayton-davis-for-variety-the.html
    Sep 8, 2026 · original
    Clayton Davis for Variety : The smartest defense is baked into the movie’s DNA. This is not a redemption tour. It is a study of the impossibility of ever knowing what is real, which is either the perfect subject for a branch that fetishizes authenticity or a provocation aimed straight at it. Max Fisher for Newpress : China quietly saved the world last month. Max Kozlov for Nature : The NIH is quietly restricting funding for research that evaluates how public policy impacts human health. Ba-dump.
  4. America tried to buy a cure for cancer and failed. Maybe it's time for a different approach.
    Sep 7, 2026 · original
    Frequent Infinite Regress linkee Ruxandra Tesslo wrote an op-ed for The New York Times about why we can t get new cancer cures. Unsurprising for those who have read her past work, she places the bulk of the blame on the glacial speed by which clinical trials are designed, set up and run, at least in the US. Biotechs are looking at other countries — yes, including China — for their next first-in-human trial. All the cures we need are right there in the lab, you see, it is these darn trials that are too slow, keeping patients away from life-saving medicines. There is a nice n-of-one story about a patient with KRAS-mutated lung cancer who received a RAS inhibitor in a phase 1 trial to set the tone. Vinay Prasad calls out a few big omissions in Tesslo s article, and the number one point he brings out is the number one point I have issue with as well: the science is, in fact, lacking. There a
  5. https://blog.miljko.org/2026/09/05/alex-tabarrok-writes-that-it.html
    Sep 6, 2026 · original
    Alex Tabarrok writes that it doesn t matter if the workers share of GDP shrinks because of AI. As long as the pie is bigger — and our AI oligarchs say it can be as much as 10% bigger each year! — the average worker will have a bigger share in absolute terms if not in relative. Hogwash. The one who has the bigger slice has the power to lord over the ones with smaller slices so the relative size does in fact matter. Never mind that our sense of wellbeing is itself ties to how we perceive ourselves in the overall community. What Tabarrok proposes is voluntary serfdom. I think not.
  6. https://blog.miljko.org/2026/09/05/my-quarterly-now-page-update.html
    Sep 5, 2026 · original
    My quarterly Now page update is up. Nothing s new and everything is, depending on your point of view.
  7. Saturday links, assorted
    Sep 5, 2026 · original
    Dan Luu: Ed Zitron s AI prediction track record . Not great. I have linked to Zitron a few times , to articles that were short enough for me to actually read and understand. Most of them were just too long and/or too angry. Fitting that a critique of Zitron s writing is just as long, though much more even-keel. Lilly Lynch: Sympathy for the Devil? Lindsay Clancy, Mercy and Maternal Filicide in History . The less I know about this case the better, but this was some good context. Ernie Smith: Wanted: Some Cheap Computing . Issue No. 1 of Smith s mini-PC newsletter. I am in the market for both a heavy-duty primary machine and some satellite servers, and thanks to the ramapocalypse the latter — and therefore this newsletter — is much more appealing. Derek Sivers: Bangalore India hospital flow . Today I learned Sivers was a fan of executive health checks . Yikes! As I wrote in a comment to th
  8. https://blog.miljko.org/2026/09/02/i-did-it-i-used.html
    Sep 2, 2026 · original
    I did it. I used overmorrow in a progress note today. Doing my part to bring it back.
  9. Wednesday links, nice and short
    Sep 2, 2026 · original
    Elizabeth Preston for the Audubon magazine: Are Crows Really Our Friends? Of course not. David Allen: Are you trying to be too organized? You’re better off being a good carpenter with a simple hammer than a novice with a garage full of unused power tools. Alex Chalmers & Rob Wiblin: Just bury your trash . The Penn & Teller: Bullshit! episode on recycling is 22 years old yet still relevant.
  10. https://blog.miljko.org/2026/08/29/calling-it-now-quietly-is.html
    Aug 30, 2026 · original
    Calling it now: “quietly” is Word of the Year 2026. What AI sired, mindless zeitgeist reverberators now rear.
  11. https://blog.miljko.org/2026/08/29/havent-mentioned-it-in-a.html
    Aug 29, 2026 · original
    Haven t mentioned it in a while , but my move away from Apple continues. Pixel 10a purchased, GrapheneOS installed. Alea iacta est.
  12. Friday links, all FT
    Aug 28, 2026 · original
    Michael Peel and Antonia Cundy: The cowboy clinics selling unproven longevity treatments . Wherein two FT reportes pose as patients and get to hear some ridiculous promises. How on Earth do these supposed doctors get to keep their licenses ? Robert Armstrong: The US consumer is showing some strain . Great data analysis work. If only people gave that much scrutiny to biomedcial research. Miranda Green: Have you got 10 minutes? No? Neither do I. Madhumita Murgia: Anthropic launches AI tool that can conduct scientific experiments . As if science wasn t slop-ridden already. Says the text: AI has become increasingly important to drug research at big pharmaceutical companies. Eli Lilly, maker of popular weight-loss drugs, has partnered with AI chipmaker Nvidia chips and earlier this year invested in Insilico Medicine, a company focused on AI for drug discovery. Please. I would wait until any o
  13. In defense of lawyers
    Aug 26, 2026 · original
    The more I think about Dan Wang s book Breakneck the less I think of it. Wang presents America as a country of lawyers — orderly, slow, nothing gets done — and China as a country of engineers, moving fast and breaking things, some of the breakages being described in detail. If only America was ruled more by engineers, or China had more lawyers involved, and we d have two great countries instead of two deeply flawed ones. I would suggest that the true dichotomy Wang described is not one between lawyers and engineers, but one between rule of law and rule by law. If it ever appears that projects are being bogged down in legalese, I would posit that it is not because too many lawyers are involved but rather than an appropriate number of lawyers is trying to, and I am choosing my words carefully here, stop stupid shit being done. They are not always successful but at least they try. So if it
  14. https://blog.miljko.org/2026/08/25/one-of-many-many-details.html
    Aug 25, 2026 · original
    One of many, many details at Meow Wolf Denver . As our teenager — the one pretend-holding this house — noted, it’s like being dropped right into the robot city level of Stray . Parts of it aren’t too far off from Planescape: Torment either. I suspect we’ll keep coming back.
  15. Saturday links, late edition
    Aug 23, 2026 · original
    Kyla Scanlon: How to Get Rich in America . A tragedy in five parts. Part four in particular reminded me of my own travails . Protesilaos: About desire, authenticity, and moderation . No notes. Dorothy Bishop: Acceleration of the arms race between fraudsters and honest researchers . An authentic scientist against the world. Cory Doctorow: The actual epistemic crisis . Pairs nicely with the above. Ryan Cross for Endpoints News: Exclusive: Third death in China s popular but opaque trials revealed, this time in CAR-T . Behind a paywall, but the title is comprehensive enough. It was for an in vivo CAR-T trial using circular RNA. Unsurprising . Adam Mastroianni: **I like em thick . No notes, again. Aidan Walker: shift, slop, chud: operating a vibe . Contains the sentence of the week: The media class continued to read X like a thermometer offering data about the climate of opinion when it was a
  16. https://blog.miljko.org/2026/08/18/part-deux-of-the-rainbow.html
    Aug 19, 2026 · original
    Part deux of the rainbow bonanza in Cherry Creek North this weekend. Our kids were making fun of my wife and me. “Dad, it’s just a rainbow, geez.” Four and some decades and I don’t remember ever seeing something like this in Europe. Or the East coast for that matter.
  17. https://blog.miljko.org/2026/08/18/ok-some-of-it-is.html
    Aug 19, 2026 · original
    OK, some of it is Apple’s agressive post-processing. But this was quite the double rainbow.
  18. Saturday links, biotech and medicine
    Aug 15, 2026 · original
    Saloni Dattani: Every disease is a policy failure . A good overview of how far we ve come in treating many diseases, but also a thoroughly depressing perspective and one that I can t endorse. It s like saying poverty is a policy failure. No. Poverty and disease are the default state of the human condition. We should celebrate and cherish each step away from them; beating ourselves up over our imperfections in eliminating them is the road to madness. Hugh Rienhoff for the FT: Biotech VCs have become like bankers and we might all pay the price . With the above in mind, I think we can agree that financialization of drug development has brought asymmetric returns to the parties involved, and the closer you are to the actual science the further you are from the rewards. The bankers always win. Rahul Parikh and Jonathan Mates for Nautilus: The Trouble with Cancer Screening . There is a school
  19. https://blog.miljko.org/2026/08/15/this-chart-is-a-close.html
    Aug 15, 2026 · original
    This chart is a close relative to you are not stuck in traffic, you are the traffic. Marginal Revolution comments, as usual, have it right; the actual chart title doesn t.
  20. https://blog.miljko.org/2026/08/13/how-can-you-not-like.html
    Aug 14, 2026 · original
    “How can you not like Ted Lasso?” I asked my 9-year old daughter. “Because we’re not middle-aged people.” Fair.

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